Changes in brain development are accompanied by changes in the virus’s proclivity for different cell types. One nonclinical study showed that although the virus crossed the BBB, it preferentially ...

A membrane-like surface that prevents viruses and pathogens from entering the brain, the BBB is a hindrance to the direct entry of drugs into the brain similarly by filtering out active ...

A human polyomavirus, known as John Cunningham virus (JCV), has evolved the natural ability to penetrate and cross the BBB and enter the brain, where it causes progressive multifocal ...

The blood–brain barrier (BBB) is meant to protect the brain from noxious agents; however, it also significantly hinders the delivery of therapeutics to the brain. Several strategies have been ...

The BBB forms a highly regulated vascular ... 1 O-glycan,” was knocked down in mouse brain endothelial cells using an adeno-associated virus (AAV) targeting approach. C1galt1 knockdown resulted ...

A new study reveals that herpes simplex virus-1 (HSV-1), commonly known for causing cold sores, can travel through the nasal ...

Adeno-associated virus (AAV) vectors are also being explored ... which has been reported to achieve penetration of the blood–brain barrier (BBB) after intravenous administration.