Learn how nanoparticles cross the blood-brain barrier (BBB) and explore their potential in treating neurological disorders ...

The blood–brain barrier acts as a strict control point for what can enter the brain, and is created by tight junctions between endothelial cells lining blood vessels, astroyctic endfeet and a ...

The blood–brain barrier (BBB) is meant to protect the brain ... which constitute the anatomical basis of BBB, form tight junctions due to a lack of fenestration and reduce the diffusion of ...

As these tight junctions deteriorated, more blood proteins and T cells ... The findings come hot on the heels of another paper that reported the blood-brain barrier breaks down with age as the ...

In addition to a thick skull, the blood-brain barrier (BBB), a natural protective membrane ... The BBB consists of tight junctions that connect endothelial cells — the cells lining the inside of blood ...

There, senescent cells stimulated macrophages in the choroid plexus to secrete cathepsin S, breaking down tight junctions and causing leakage (March 2025 news). Bottlebrush Barrier. The glycocalyx ...

Researchers led by CHLA’s Jonathan D. Santoro, MD, have identified signs of neuroinflammation and dysfunction of the ...

They were watching brain scans of a woman named Bonny Hall, who lay inside an MRI machine just a few feet away. Earlier that day, Hall, who had been battling a brain tumor for eight years, had ...

"Our model takes a new approach to mimic the blood-brain barrier outside of a living system. These miniature spheroids are relatively straightforward to culture, and yet it is able to reproduce many ...

A 3D model accurately mimicking the blood-brain barrier (BBB) in a laboratory environment ... arrangement and organization process of "tight junction proteins," a component typically absent ...

Researchers have developed a method for the localized delivery of blood-borne drugs using magnetic nanoparticles. A critical barrier to delivering drugs ... effect could disrupt the endothelial ...