leaky blood–brain barriers (BBB), and ultimately neuronal death. Neurovascular dysfunction represents the earliest and strongest brain pathology associated with AD 1. SNP318 is a small molecule ...

The Ability of Drugs to Penetrate the Blood–Brain Barrier The blood–brain barrier (BBB) is the main obstacle to the penetration of most drugs into the brain parenchyma and, in other types of ...

The blood–brain barrier (BBB) is meant to protect the brain from noxious agents; however, it also significantly hinders the delivery of therapeutics to the brain. Several strategies have been ...

MNPs can efficiently cross the BBB, which could help improve the peptide’s delivery to the brain. Additionally ... that the complex transversed the BBB and led to reduced tau pathology in their brains ...

Malignant gliomas and medulloblastomas — the most common brain tumours affecting adults and children, respectively — remain responsible for a disproportionate level of morbidity and mortality ...

39,40 Pathologic GM lesions are present in the brain early on and have a clear relationship to cognitive impairment. Although GM pathology has become more evident, mainly through novel imaging ...

“The systemic delivery of mRNA molecules to the central nervous system is challenging as they need to cross the blood-brain barrier (BBB) to reach into the brain. Here we design and synthesize ...

in various neurodegenerative conditions and as a result of brain injury, can accumulate as tangled toxic deposits. Using a recently developed in vivo imaging technique, researchers have now examined ...