Apoptosis, a process important for clearing ... A primary responder in this pathway is caspase-8, known to be recruited via its Death effector domains (DEDs) to the activated DRs to form a complex ...

Figure 4: Reduced caspase activation in Pml ... ceramide and IFN apoptotic pathways normally deputed to induce apoptosis upon DNA damage or neoplastic transformation.

A recent study has unveiled the pivotal role of Ferroptosis Suppressor Protein 1 (FSP1) in intervertebral disc degeneration ...

Scientists commonly use caspase assays to evaluate apoptosis, evaluating caspase activation—a hallmark of apoptosis initiation—with fluorescent dyes. Researchers often perform multiplex caspase assays ...

Breast cancer is one of the leading causes of mortality among women worldwide. Tumor necrosis factor α-induced protein 3-interacting protein 1 (TNIP1) is a ubiquitin-binding protein that is widely ...

The primary interest of our lab is to investigate the molecular mechanisms of apoptosis and how they impact human ... disk confocal microscope to perform single cell analysis of caspase pathways.