Brown and Goldstein were awarded the Nobel Prize for their outstanding contributions to the study of cholesterol metabolism, including their discovery of receptor-mediated endocytosis. In 1975 ...

Reduced receptor-mediated LDL endocytosis causing raised blood LDL cholesterol (LDL-C) is the main defect, but other abnormalities due to lack of LDL receptors include altered hepatic cholesterol ...

Nowhere is the interdisciplinary nature of cell biology better illustrated than in the field of endocytosis. In recent years, it has become clear not only that a better understanding of ...