Endothelial cells that lack functional cilia are less sensitive to VEGF-A compared to normal endothelial cells, resulting in impaired signalling via the VEGFR2 receptor.

Endothelial cells that lack functional cilia are less sensitive to VEGF-A compared to normal endothelial cells, resulting in impaired signalling via the VEGFR2 receptor.

The authors show for the first time that mouse and human lymphatic endothelial cells (LECs) - which make up the inner and outer lining of lymphatic vessels - use primary cilia.

In recent years, researchers have been learning more about why cellular antennas called cilia are so important. Cilia can act as sensors of the cell's environment and can send and receive signals.

Revealing new biology. Cilia are notoriously difficult to study. In brain cells, a single cilium, only tens of microns long, extends from a cell's surface into a jumble of other cells.

Endothelial cells that lack functional cilia are less sensitive to VEGF-A compared to normal endothelial cells, resulting in impaired signalling via the VEGFR2 receptor.

A group of rare diseases called "ciliopathies"—polycystic kidney disease notable among them—emerge from defects in cilia, the tiny hair-like structures on the surface of almost every cell type.

Dysfunctions of the tiny cell processes (primary cilia) of the pancreatic beta cells could be a cause of type 2 diabetes. Little is known about the structure and function of these cilia.

Dec. 4, 2020 — A new study shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the blood supply and delivery of glucose to the insulin ...

Specialized cells in our bodies have custom genetic Xerox machines to make a ton of fibrous cilia, scientists at John Hopkins University School of Medicine have found. Most cells in the body have ...

Cilia may be capable of much more than acting as little antennae that sense signals outside of nerve cells. The stubby appendages may actually be able to send messages themselves , results from a ...