Findings further indicated that leptin secreted by the bacteria ... that have been waiting for a way to safely cross the blood–brain barrier. More information: Haosheng Shen et al, Engineered ...

The blood–brain barrier (BBB) is often an obstacle for ... They then chose Lp to deliver the appetite regulating hormone, leptin, which activates the leptin receptor (LEPR) mostly expressed ...

Aging brains may struggle to clear out waste, contributing to memory loss and diseases like Alzheimer’s. But researchers have now found that improving the brain’s waste-draining vessels in old mice ...

The blood-CSF barrier has been far less studied than the blood-brain barrier. Scientists have detected age-related changes in gene expression in the choroid plexus, and have linked these to increased ...

1 Department of Pharmaceutical Sciences, University of Modena & Reggio Emilia, Via Campi, 41100 Modena, Italy. 2 Department of Biomedical Sciences, University of Modena & Reggio Emilia, Via Campi ...

That's when the leptin circuit evolved. Neurons in the hypothalamus-the brain's energy-balance regulator-pick up satiety signals from fat, which secretes leptin; a high amount of the hormone ...

Some gut hormones may also act directly on hypothalamic nuclei via the circulation and across an incomplete blood-brain barrier ... and nucleus accumbens. Leptin is also thought to act directly ...

Scientists suggest study findings could point to the future development of new treatments for age-related cognitive decline.