The ability of leptin to cross the blood-brain barrier in affected individuals Genes that regulate the production of leptin ...

After some high-profile crashes, the one-time biotech darling is inching toward success with its Hunter syndrome treatment, which today began a rolling BLA for accelerated approval.

"We're focusing on reducing the size of the leptin molecules to increase the likelihood of crossing the blood-brain barrier," Harvey added. But the drug could be years away, she said. "Developing ...

Some gut hormones may also act directly on hypothalamic nuclei via the circulation and across an incomplete blood-brain barrier ... and nucleus accumbens. Leptin is also thought to act directly ...

The blood–brain barrier (BBB) is meant to protect the brain from noxious agents; however, it also significantly hinders the delivery of therapeutics to the brain. Several strategies have been ...

Oregon State University researchers have discovered a way to get anti-inflammatory medicine across the blood-brain barrier, opening the door to potential new therapies for a range of conditions, ...

Santoro, MD, Director of the Neuroimmunology Program at Children's Hospital Los Angeles, shows evidence of dysfunction of the blood-brain barrier and inflammation in the central nervous system in ...

ABL Bio Inc. sealed a potential £2.075 billion (US$2.65 billion) license deal with GSK plc, granting GSK global rights to use ABL’s blood-brain barrier penetrating bispecific antibody platform, ...