Lysosomes contain catabolic hydrolases that participate in the digestion of autophagic material (after fusion between lysosomes and autophagosomes), in acute cell death (after lysosomal-membrane ...

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death. Controlled death of cells, or programmed ...

The team discovered that peroxidation of lysosomes plays a key role in the execution of ferroptosis-mediated cell death. Additionally, they found that lysosomal lipid peroxidation causes the membrane ...

For many years, lysosomes have been thought to be solely involved in necrotic and autophagic cell death, with their role in apoptosis being limited to the digestion of engulfed apoptotic bodies ...

Chinese scientists recently reported the key role of histone acetylation-regulated long noncoding RNA termed as lysosome cell death regulator (LCDR) in tumor survival, providing a potential ...

A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of ...

This study unravels that ferroptosis, an iron-mediated cell death characterized by lipid oxidation, can be initiated in lysosomes. Ferroptosis has been gathering an increased interest in cancer ...

Many people with IBD, an umbrella term that includes ulcerative colitis and Crohn's disease, have a reduced quality of life, ...

Lysosomes are basically the cell’s trash and recycling centers. “I don’t think it’s possible for lysosomes to all pop at the same time,” Omsland said.

Ferroptosis, a form of programmed cell death mediated by iron, has been a focus for its potential in cancer therapies. Now, researchers have discovered that lysosomal lipid peroxidation plays a ...