For cell isolation, human lung tissues were obtained from patients ... The cells were incubated with primary antibodies as follows: mouse anti-human surfactant protein-A (SP-A) monoclonal antibody ...

which then potently suppressed inflammation in this mouse model of neutrophilic asthma. More information: Vijay Raaj Ravi et ...

Researchers have developed a new mouse model of LAM (pulmonary lymphangioleiomyomatosis ... by proliferation of smooth muscle-like cells in the lung, destruction of lung tissue, and growth ...

This approach enabled over 70% editing efficiency in mouse lung stem cells, sustaining the effect for up to 660 days, a result which, if translated into the clinic, may offer the potential for ...

In a mouse model of non-small cell lung cancer (NSCLC), this delivery system, loaded with CRISPR-Cas9, effectively targets the lung, ablating the tumor and extending survival time. Thanks to this ...

Researchers have identified a lung stem cell that repairs the organ's gas exchange compartment. They isolated and characterized these progenitor cells from mouse and human lungs and demonstrated ...

Lung cancer cells (red) in the mouse lung adapt to KRAS inhibition (green). This adaptation allows the cells to withstand KRAS inhibitor therapy and can give rise to lung cancer resurgence later on. A ...

Lung cancer is a leading cause of cancer deaths around the world, and is often not diagnosed until it is in late stages that are frequently untreatable. Scientists have used a mouse model to identify ...

Tissue dissociation is a crucial sample preparation step that enables the isolation of specific cell populations for downstream applications such as single-cell RNA sequencing. Enzymatic tissue ...

BIRMINGHAM, Ala. – Researchers have reversed lung fibrosis in a mouse model of idiopathic pulmonary fibrosis, or IPF, as reported in a study published in the journal Cell Death and Differentiation.