By influencing calcium homeostasis, local protein synthesis and the endoplasmic reticulum, a small protein called Rab10 emerges as a crucial cytoplasmic regulator of neuropeptide secretion.

They should also be capable of trans-synaptic signaling and act to redistribute pre- and postsynaptic proteins. A prime example of such an inducer is agrin. A neuron-specific splice variant of ...

This results in enough neurotransmitter being diffused across the synaptic cleft to trigger the impulse in the postsynaptic neuron. This process is called summation.