Here are Wednesday’s winning lottery numbers: The estimated Powerball jackpot is $325 million. The lump sum payment before taxes would be about $145.3 million.

The Bills ran 11-on-11 drills in the red zone to ratchet up the competition between the offense and defense on Day 1 at St. John Fisher University. Bills quarterback Josh Allen said the first day was ...

New York — U.S. Rep. Mike Lawler, a moderate Republican representing a suburban New York swing district, said Wednesday he won’t run for governor next year.

The Buffalo Bills began training camp on Wednesday and they did so without two key starters who are out battling injuries. Veteran tight end Dawson Knox was placed on the non-football injury list (NFI ...

Rachael DeWitt, 31, began a 16-mile swim of Skaneateles Lake today, pushing off the concrete seawall in the village shortly ...

The Buffalo Bills announced a few roster moves on Tuesday, just a day before the team opens training camp at St. John Fisher ...

The iconic headgear from the Super Bowl era will make its return for the regular-season finale against the New York Jets, ...

Two health care companies are positioned to keep tens of millions of dollars that are meant to benefit the army of low-wage ...

Hancock, N.Y. — An Upstate fire chief was electrocuted Thursday night after responding to a crash where downed wires touched ...

An AMBER Alert was issued early Sunday morning for the girl, who police originally said was taken in Lake George.

A police chief in Upstate New York has been placed on leave after his girlfriend was arrested over an altercation.

Shuffield co-founded Fastball in the 1990s with lead singer and multi-instrumentalist Tony Scalzo and guitarist-vocalist ...