Among them, MMP-9 plays a particularly significant ... in treating brain cancer is delivering drugs across the blood-brain barrier, a protective layer that prevents many therapeutic compounds ...

(IEC, Intestinal Epithelial Cells; MMP, Matrix Metalloproteinase ... short-chain fatty acids; BBB, blood-brain barrier.). During the early stages of ischemic injury, DAMPs and cytokines expressed at ...

This effect was likely due to its ability to inhibit the p-ERK/p-p38MAPK pathway and downregulate the expression of MMP-15. In their investigation ... and difficulty in crossing the blood-brain ...

As aging bodies decline, the brain loses the ability to cleanse itself of waste, a scenario that scientists think could be ...

Aging brains may struggle to clear out waste, contributing to memory loss and diseases like Alzheimer’s. But researchers have now found that improving the brain’s waste-draining vessels in old mice ...

Researchers of a new study have discovered that DSRD patients showed signs of neuroinflammation and blood-brain barrier ...

A slimy barrier lining the brain’s blood vessels could hold the key to shielding the organ from the harmful effects of ageing, according to a study in mice. The finding shines a spotlight on a ...

Getting mRNA into the brain could allow scientists to instruct brain cells to produce therapeutic proteins that can help ...

The blood-CSF barrier has been far less studied than the blood-brain barrier. Scientists have detected age-related changes in gene expression in the choroid plexus, and have linked these to increased ...

In a study in aging mice, Shi has uncovered striking age-related changes in the sugary coating – called the glycocalyx – on cells that form the blood-brain barrier, a structure that protects the brain ...