These cells lining the inside of your brain's blood vessels are tightly packed together, forming your blood-brain barrier.

The Ability of Drugs to Penetrate the Blood–Brain Barrier The blood–brain barrier (BBB) is the main obstacle to the penetration of most drugs into the brain parenchyma and, in other types of ...

However, tPA can only be safely administered within 3 hours following stroke onset, as beyond this, the integrity of the blood–brain barrier (BBB) is compromised, and haemorrhagic complications ...

Ischemic stroke results from an obstruction of a blood vessel supplying blood to the brain. The brain is an organ extremely sensitive to reduction of oxygen and energy, and brain damage is already ...

However, the effect of IL-1RA on blood-brain barrier disruption following ischemia-reperfusion has not been reported. METHODS: In this study, we investigated the effects of IL-1RA and a novel ...