Designing BBB organoids posed a technical challenge: growing the two components—the brain ... blood vessels in the BBB. In contrast, blood vessel organoids did not express these molecules before ...

Researchers at the National University of Singapore have reported crossing the blood–brain barrier with help from a modified Lactobacillus plantarum. By delivering an appetite-regulating hormone ...

For decades, scientists across the globe have investigated methods to accurately measure drug permeability across the ...

glial cells and the blood-brain barrier following ischemic insult. We also describe the evidence of TRPM2 involvement in these processes, as shown from numerous in vitro and in vivo studies that ...

A well-known in vitro model of the blood-brain barrier that is widely used in studies of neurodegenerative diseases and in preclinical research is made from the wrong kind of cells, according to ...

The blood–brain barrier (BBB) is meant to protect the brain from noxious agents; however, it also significantly hinders the delivery of therapeutics to the brain. Several strategies have been ...

In patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting ...

A 3D model accurately mimicking the Blood-Brain Barrier (BBB) in a laboratory environment has been successfully developed by research teams led by Professor Jinah Jang from the Departments of ...

ABL Bio’s first-in-class bispecific antibodies for Parkinson’s disease combine unprecedented blood–brain barrier penetration ... with other SNCA homologs in vitro, and has shown in vivo ...

Damage to the blood–brain barrier is known to contribute to the ... the damaging effects of blood from CKD patients on cells in vitro. They now hope to move the work forward to a clinical ...

Following the devastating fires that swept through Los Angeles in January, concerns are on the rise about the long-term ...