For cell isolation, human lung tissues were obtained from patients ... The cells were incubated with primary antibodies as follows: mouse anti-human surfactant protein-A (SP-A) monoclonal antibody ...

Researchers have developed a new mouse model of LAM (pulmonary lymphangioleiomyomatosis ... by proliferation of smooth muscle-like cells in the lung, destruction of lung tissue, and growth ...

which then potently suppressed inflammation in this mouse model of neutrophilic asthma. More information: Vijay Raaj Ravi et ...

Researchers have identified a lung stem cell that repairs the organ's gas exchange compartment. They isolated and characterized these progenitor cells from mouse and human lungs and demonstrated ...

Tissue dissociation is a crucial sample preparation step that enables the isolation of specific cell populations for downstream applications such as single-cell RNA sequencing. Enzymatic tissue ...

to simulate asthma attacks in living mouse lung cells primed to be hyperresponsive. Fifteen minutes of constricting the airways caused severe crowding of epithelial cells and led to an excess of ...

Lung cancer cells (red) in the mouse lung adapt to KRAS inhibition (green). This adaptation allows the cells to withstand KRAS inhibitor therapy and can give rise to lung cancer resurgence later on. A ...

Lung cancer is a leading cause of cancer deaths around the world, and is often not diagnosed until it is in late stages that are frequently untreatable. Scientists have used a mouse model to identify ...

Two independent research teams have used single-cell RNA sequencing ... atlases of mouse and human airway cells. The findings, reported in two studies today (August 1) in Nature, reveal the ...

In a mouse model of non-small cell lung cancer (NSCLC), this delivery system, loaded with CRISPR-Cas9, effectively targets the lung, ablating the tumor and extending survival time. Thanks to this ...