How to clear the toxic tau protein that can lead to Alzheimer's and related diseases
The neurotransmitter glutamate is essential for regulating everything from mood to memory, but it can also encourage a toxic ...
Technology Networks14d
Targeting Lysosomes Could Halt Tau Accumulation in Alzheimer’s
A study reveals how glutamate drives tau accumulation in Alzheimer’s and related disorders. Researchers found that blocking the gene KCTD20 activates lysosomes, helping clear toxic tau proteins in lab ...
The Scientist2y
Scientists Uncover Major Pathway Cells Use to Mend Leaky Lysosomes
Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say. Holly Barker is a freelance journalist ...
Hosted on MSN1mon
Inability of cells to recycle fats can spell disease: Study reveals how a protein helps transport fats out of lysosomes
Fats and other cellular materials reach the lysosome through three main pathways: endocytosis, phagocytosis, and autophagy. In endocytosis, the cell takes in materials from outside by wrapping ...
pharmaphorum1y
MSD reaches $610m deal to buy lysosome biotech Caraway
It has a range of preclinical-stage projects that aim to harness lysosomes’ ability to clear ... lateral sclerosis (ALS), also known as motor neuron disease (MND). In 2020, the biotech was ...