Here, we explored how NMDARs signal in tLTD. We found that, regardless of frequency, L5 PC→PC tLTD relies on the non-ionotropic preNMDAR signaling pathway mediated by JNK2, which helps to resolve the ...

By influencing calcium homeostasis, local protein synthesis and the endoplasmic reticulum, a small protein called Rab10 emerges as a crucial cytoplasmic regulator of neuropeptide secretion.

Cameron Faulkner (he/him) is Polygon’s commerce editor. He’s a product expert who began writing about tech and gaming in 2013, and migrated from The Verge in 2023. The original article follows ...

A girl with polio meets one of the first children to get a polio vaccine. Bettmann/Getty Images By Elena Conis Graphics by Sara Chodosh and Aileen Clarke Dr. Conis is a historian of medicine and ...

MANILA, Philippines — Malacañang has described the International Criminal Court’s (ICC) pre-trial proceedings on former president Rodrigo Duterte’s drug war case as “fair,” saying that ...

On March 14, 2025, at the International Criminal Court in The Hague, Netherlands, members of Pre-Trial Chamber I—Presiding Judge Iulia Antoanella Motoc, Judge Reine Adélaïde Sophie Alapini ...

Researchers devised a process to convert a skin cell directly into a neuron, eliminating the need to generate induced pluripotent stem cells. Such neurons could be used to treat spinal cord ...

MANILA, Philippines — Former President Rodrigo Duterte is set to make his first appearance before the International Criminal Court’s (ICC) Pre-Trial Chamber I at 9 p.m. (PST) on Friday, March 14.

Nintendo Switch 2 pre-orders have been delayed in the U.S. as confirmed to Tom's Guide via an official statement. Switch 2 was set to be available to pre-order this week (on April 8) but due to a ...

Pre-orders for the Nintendo Switch 2 have already opened early in the UK, with US retailers set to offer the console from 9 April 2025. You can find out the current pre-order locations and links ...