Li's lab studies the lysosome, and in particular, the composition of lysosome membrane proteins. The lysosome has the ability to regulate its own membrane protein by triggering the degradation of ...

Li’s lab studies the lysosome, and in particular, the composition of lysosome membrane proteins. The lysosome has the ability to regulate its own membrane protein by triggering the degradation ...

Li's lab studies the lysosome, and in particular, the composition of lysosome membrane proteins. The lysosome has the ability to regulate its own membrane protein by triggering the degradation of ...

However, some proteins can bypass this system using unconventional mechanisms, including direct translocation across the plasma membrane, transporter-mediated secretion, and intracellular vesicle ...

Scientists at the University of Pittsburgh have discovered a new signaling pathway (PITT) essential for rapid repair of breaches in the lysosomal membrane. The PITT pathway is activated by ...

Tan says the findings could point to drug targets for neurodegenerative diseases, such as Alzheimer’s, as protein aggregates like tau escape in the lysosome membrane, preventing their destruction and ...

Contrary to long-standing assumptions, human egg cells stay pristine for decades not by ramping up waste disposal, but by ...

That's because lysosome membrane proteins are transported from the endoplasmic reticulum. While the lysosome is being built, it needs a lot of trafficking proteins.

Overview: Both mitochondrial and lysosomal stress stimulate TFEB nuclear translocation, followed by increased HKDC1 expression. HKDC1 stabilizes PINK1 through interaction with TOM70, thereby ...

Proteins are conventionally trafficked and secreted ... The KFERQ-like motifs of monomeric PARK7 selectively bind to HSPA8 chaperones and are recruited to the lysosomal membrane, ...