Rocket Pharmaceuticals' gene therapies offer long-term effects for cardiovascular and hematology diseases. Read why I rate ...

Membrane proteins are proteins found in cell membranes ... or a hydrophobic protein patch. The lysosomal enzyme beta-glucocerebrosidase is a key player and promising therapeutic target in ...

A biotech company advancing next-generation targeted protein degradation (TPD) therapies for intractable diseases.

Alzheimer's disease is one of the world’s most prevalent brain disorders, being extremely difficult to treat. Alzheimer's ...

Breakthroughs in microscopy are illuminating organelle interactions, providing critical insights into cellular processes and ...

Protein degrader specialist Lycia Therapeutics completed a $107 million Series C financing that will be used to move its lead lysosomal targeting chimaera (LYTAC) candidates into clinical testing ...

Upon lysosomal damage, cells deploy defensive mechanisms, including a key process called CASM (conjugation of ATG8 to single membranes), which lipidates ATG8 proteins onto the limiting membrane to ...

We have detected a significant decrease of pS211-TFEB protein in brain tissues of NPC mice ... clearly present inside lysosome (LAMP1 labelled lysosomal membrane, green signal), suggesting that ...

Ultrastructural analysis showed that these structures were large spherical membrane assemblies, including endosomes, lysosomes, and tubulo-vesicular structures located in the periphery of the PM. We ...

LC3II is integrated into the nascent phagosome membrane and acts as a marker that facilitates ... help complete phagosome formation and target it to the lysosome for degradation. Although these ...

Using a novel method that gives a readout of which proteins are in specific locations within cells, UT Southwestern Medical ...