Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ ...

Systemic therapy represents the standard of care treatment for patients with advanced hepatocellular carcinoma (HCC). Given the increased risk of death from cirrhosis-related complications in patients ...

Background Inflammatory bowel diseases (IBDs) are characterised by dysbiosis and a leaky gut. The NADPH oxidase dual oxidase 2 (DUOX2) is upregulated in patients with IBD, yet its role in driving the ...

Lymphocytic gastritis is a histopathological entity characterised by the accumulation of small lymphocytes in the surface and foveolar epithelium. In order to investigate the correlation between ...

Correspondence to Brian B Scott, Department of Medicine, Lincoln County Hospital, Lincoln LN2 5QY, UK; drbbscott{at}aol.com Iron deficiency anaemia (IDA) occurs in 2–5% of adult men and postmenopausal ...

Background—Black tea is known to be a potent inhibitor of intestinal absorption of non-haem iron at least in healthy subjects. Aims—To investigate this effect in patients with genetic haemochromatosis ...

Correspondence to Professor Jin-Woo Bae, Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University, Seoul 02447, Republic of Korea; baejw{at}khu.ac.kr; ...

Background Acute appendicitis is a local intestinal inflammation with unclear origin. The aim was to test whether bacteria in appendicitis differ in composition to bacteria found in caecal biopsies ...

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Objective Chronic alcohol consumption is an important cause of liver-related deaths. Specific intestinal microbiota profiles are associated with susceptibility or resistance to alcoholic liver disease ...

Correspondence to Dr Seungil Ro, Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557-0046, USA; sro{at}unr.edu Diarrhoea occurs from excessive production of serotonin ...

Introduction The first line treatment for constipation is centred on fibre including increasing dietary fibre and/or fibre supplements. However, fermentable fibres can exacerbate other ...