Typically, endocytosis is facilitated with a protein called clathrin, but clathrin was not involved in the absorption of small extracellular vesicles into their target cells.

Classically, endocytosis involves the formation of clathrin-coated carriers that bud from the plasma membrane by dynamin-dependent mechanisms. Recently, several clathrin-independent endocytic ...

1.1 Clathrin-independent endocytosis. Although CCV purification permitted identification of CME machinery proteins, evidence of additional pathways predated the discovery of coated pits (Keen et al., ...

Clathrin-dependent and -independent pathways also contribute to β1 integrin endocytosis . Integrins are a family of transmembrane receptors that integrate cell adhesion to the extracellular matrix ...

Thank you for submitting your article "The AP-2 complex has a specialized clathrin-independent role in apical endocytosis and polar growth in fungi" for consideration by eLife.Your article has been ...

Filamentous fungi provide excellent systems for investigating the role of the AP-2 complex in polar growth. Using Aspergillus nidulans, we show that AP-2 has a clathrin-independent essential role in ...

Endocytosis controls many functions including nutrient uptake, cell division, migration and signal transduction. A clathrin‐ and caveolin‐independent endocytosis pathway is used by important ...

Using similar cells, we have examined if this is also the case for clathrin-independent pathways, including caveolae-mediated endocytosis and macropinocytosis. We observed impaired caveolin-1 ...

In addition, we have identified what we believe to be the first factors specifically involved in the clathrin‐independent endocytosis of IL‐2Rβ, that is, the serine/threonine kinases Pak1 and Pak2, ...

Such clathrin-independent endocytosis of CD40 prompted us to ask whether a lipid raft-dependent pathway might be involved in regulation of CD40 internalization in ECs. Lipid rafts can be ...