To investigate a possible role of primary cilia in endothelial repair in vivo, we produced a linear endothelial wound in the CE of adult mice. The wound was generated by gently scraping cells with a ...

Brain endothelial cell two-cilia phenotype is specific to the G0/G1 phase of the cell cycle To assess when in the cell cycle brain microvascular ECs exhibit the two-cilia phenotype, HBMECs were ...

Cilia are present on a subset of endothelial cells where they project into the vessel lumen and are implicated as mechanical sensors of blood flow. To test the in vivo role of endothelial cilia, we ...

The promise of corneal endothelial cell therapy is being able to treat more patients with a less onerous recovery, with better outcomes and perhaps even earlier in their disease.

Recent years have seen a number of single-nuclei RNA-Seq studies of AD brain, but endothelial cells usually make up only a small fraction of those isolated (May 2019 news; Nov 2019 news). One closer ...

On balance, the model we propose is as follows: 1) Endothelial primary cilia membrane harbors components of ALK1 signaling. 2) During angiogenesis, tip cells exhibit primary cilia as they migrate and ...

When you purchase through links on our site, we may earn an affiliate commission. Here’s how it works. "Zombie cells," which often carry multiple nuclei, as shown here, accumulate in the body ...

Endothelial cells -- the cells that line blood vessels -- grown alongside leukemia cells become corrupted and rescue the cancer cells from many chemotherapy drugs, a study found.

The cells, genetically edited using CRISPR, also model ciliopathy phenotypes. In addition, human tissues and organoids derived from these cilia-free stem cells manifested ciliopathy-like symptoms.

The cilia-knockout stem cells "represent a powerful new tool for understanding this group of diseases, which can be used to guide therapy development," said Freedman, an associate professor of ...