Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of ...

Scientists at the University of California, Riverside, have discovered how adult stem cells retain their regenerative power.

This important work presents a stochastic branching process model of tumour-immune coevolution, incorporating stochastic antigenic mutation accumulation and escape within the cancer cell population.

A few years ago, the advent of technology known as CRISPR was a major breakthrough in the scientific world. Developed from a ...

This manuscript demonstrates that Oct4 overexpression synergizes with Notch inhibition (Rbpj knockout) to promote the conversion of adult murine Müller glia (MG) into bipolar cells. These findings are ...

IQVIA reported that 114 gene therapy trials were initiated in 2023, with approximately 77% sponsored by the healthcare industry. Kella Kapnisi, Head of Cell and ... with a single-dose treatment ...

Once the DNA and RNA are sequenced, a computational model reconstructs their original locations by analyzing the physical links between UMI-tags, creating a spatial map of gene expression. “We can do ...

In this study, we utilized a CRPC patient-derived xenograft model that includes both Rb pathway-proficient and -deficient cell populations based on the positive or negative expression of RB family ...

With its FDA approval for specific mutations in the RPE65 gene ... as a single subretinal injection beneath the retina in patients with confirmed RPE65 mutations and viable retinal cells.

The data pertains to the company’s lead drug candidate, Reqorsa® Gene Therapy, for the treatment of KRASG12C mutant non-small cell lung cancer (NSCLC) resistant to Ras inhibitors. The study ...