Lysosome Destabilization Is Key in Iron-Dependent Cell Death Lipid peroxidation of lysosomes plays a critical role in the execution of ferroptosis.

Recently, the permeabilization of yet another organelle, the lysosome, has been shown to initiate a cell death pathway, in specific circumstances.

Scientists in the lab of chemical engineer Monther Abu-Remaileh are uncovering the cellular functions that go awry in ...

French researchers have developed phospholipid degraders that trigger iron-catalyzed cell death in aggressive cancers like pancreatic tumors and sarcomas.

Cancer treatments necessarily target unchecked cell growth, and selectively kill cancer cells while sparing normal cells and avoiding general toxicity in the human body.

Chinese scientists recently reported the key role of histone acetylation-regulated long noncoding RNA termed as lysosome cell death regulator (LCDR) in tumor survival, providing a potential ...

Those are proteins that break stuff down. Our cells use lysosomes to help destroy germs or recycle old or messed up cell parts. Lysosomes are basically the cell’s trash and recycling centers.

Because lysosomes are the dumping site for cellular waste products, researchers are studying them in greater detail, suspecting a connection to aging. Within the past decade, scientists have shown ...

Little organs within cells called lysosomes digest unwanted material. And like stomachs, they must be acidic to do so. If they aren't, cells stop growing. Researchers wanted to know why.

By detecting lipid oxidation, the research team found that lipid oxidation in lysosomes is the cause of ferroptosis, iron mediated cell death. This results to leakage of iron from lysosomes which ...