Here, authors succeed in enlarging the noncatalytic REC domain of Streptococcus pyogenes Cas9 and harnessing this giant SpCas9 (GS-Cas9) scaffold to improve the precision of base editing.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, United States ...

This Flutter plugin allows to show embedded interactive and customizable vector maps as a Flutter widget. This project is a fork of flutter-mapbox-gl, replacing its usage of Mapbox GL libraries with ...

These scaffolds can also potentially reduce the need for autografting ... Davis Institute for Regenerative Cures (IRC) Vector Core. ECs were transduced with pCCLc-MNDU3-LUC-PGK-EGFP-WPRE or ...

We sought to characterize the structure of the 5'-UTR-IRES of the CrPV in its ribosome-bound configuration, to gain insights relating to the ribosome-binding determinants of this peculiar IRES, and to ...

The microstructure of obtained scaffolds was observed by SEM (FEI Quanta 25, USA) with energy dispersive spectroscopy (EDS). Fourier transform infrared spectroscopy (FTIR; Vector 33, Bruker, GER) were ...

Four products have already qualified for the regenerative medicine advanced therapy (RMAT) designation that provides extra interactions with the agency, and sooner. Jef Akst was managing editor of The ...

The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) that functions in early autophagy consists of the lipid kinase VPS34, the scaffolding protein VPS15, the tumor suppressor BECN1, and ...