Lysosomes are like the stomachs of cells, breaking down waste and keeping everything running smoothly. When they fail, toxic materials build up and contribute to diseases like Parkinson’s ...

Lysosomes are basically the cell’s trash and recycling centers. “I don’t think it’s possible for lysosomes to all pop at the same time,” Omsland said.

Secondary acute myeloid leukemia is a blood cancer associated with other blood disorders or previous cancer treatment. Here’s what you need to know.

The lysosome-endosomal system is tightly associated with the maintenance of cell homeostasis and viability, regulation of cell death, oncogenesis, autophagy, and inflammation (Peng et al., 2019). In ...

Lysosome integrity is essential for cell viability, and lesions in lysosome membranes are repaired by the ESCRT machinery. Here, we describe an additional mechanism for lysosome repair that is ...

GCAF (TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-33025-1 ...

The lysosome is a small membrane bound organelle that can be found in most animal cells. It was once thought that these little sacs were like recycling centers that could take up cellular waste ...

Lysosomes require tight regulation of their pH to degrade their contents. Researchers know that V-ATPase pumps protons into these little digestive sacs, but what protein shuttles the ions back out?

Lysosomes are tiny spherical sacs, ranging in size from 0.1 to 0.5 microns in diameter, bound by a lipid bilayer. They house hydrolytic enzymes that break down unwanted biomolecules or invading ...

Lysosomes are the digestive center of the cell and play important roles in human diseases, including cancer. Previous work has suggested that late endosomes, also known as multivesicular bodies (MVBs) ...