The laminin-411 protein is vital for the formation of the myelin membrane by oligodendrocytes, report researchers from Japan.

Researchers at the University of Tsukuba have discovered a unique biphasic cellular response triggered by tetrandrine, a ...

In this valuable study, the authors provide a simple yet elegant approach to identifying therapeutic targets that synergize to prevent therapeutic resistance in ovarian cancer using cell lines, ...

Human egg cells wait in the ovaries from before birth until they are finally called upon, sometimes 40 years later, to kick ...

Contrary to long-standing assumptions, human egg cells stay pristine for decades not by ramping up waste disposal, but by ...

Amyloid precursor protein (APP)-derived amyloid-β (Aβ) peptides form pathological aggregates in Alzheimer’s disease (AD).

Oocytes are long-lived cells that require specialized adaptations to maintain their fitness. This study shows that human ...

A recent study published in Genes & Diseases reveals a novel role of XPR1 in promoting ovarian cancer growth by regulating autophagy and MHC-I expression. The research, conducted by scientists from ...

Indeed, instigation of lysosome membrane damage in primary macrophages via cholesterol crystals and LLOMe triggers robust recruitment of Gal3 to lysosomes by sensing exposed carbohydrate moieties of ...

This group of proteins is known to regulate membrane trafficking and define the identity of ... with OXR1 deficiency and mice lacking Oxr1 and Ncoa7 have shown abnormal lysosomal function, which can ...

In this study published in the journal Science, researchers showed that COMMD3 knockout cells had serious issues delivering key proteins to the lysosome. They looked normal on the surface.

Here, we identified the TLDc domain-containing proteins Oxr1 and Ncoa7 as Rab-binding proteins that localize to the Golgi/TGN membrane and regulate luminal pH by inhibiting V-ATPase activity. Our ...