Using a version of the enzyme which localizes to lysosomes and a chemical known to puncture the lysosomal membrane, he was able to biotinylate all the proteins surrounding the damaged organelle. Tan ...

Membrane proteins are proteins found in cell membranes ... or a hydrophobic protein patch. The lysosomal transmembrane protein LYCHOS enables activation of the master growth regulator mTORC1 ...

Because the STING protein has multiple functional regions spanning the cell membrane, the researchers did additional experiments to determine which region might be responsible for lysosome generation.

Zhang Hong from the Institute of Biophysics of the Chinese Academy of Sciences has uncovered the molecular mechanism by which the key autophagy protein ... linked to lysosomal membrane dynamics.

Progranulin processing helps preserve lysosomal function, while prosaposin helps these ... The authors acknowledge that since they are required to traffic hundreds of plasma membrane proteins, loss-of ...

Then, they observed how cells responded to a chemical that damages the membrane that encloses lysosomes. Under normal ...

We discovered that fibroblasts and cardiac myocytes secrete mitochondria inside extracellular vesicles (EV) when their lysosomal function ... ship everything to the plasma membrane for secretion. We ...

Ferroptosis, a form of programmed cell death mediated by iron, has been a focus for its potential in cancer therapies. Now, ...

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death.